Randomized Phase II 2x2 Factorial Trial Of The Addition of Carboplatin And/Or Bevacizumab To Neoadjuvant Weekly Paclitaxel Followed By Dose-Dense AC In Hormone Receptor-Poor/HER2-Negative Resectable Breast Cancer

Summary:
The purpose of the study is to see if adding other drugs to standard neoadjuvant chemotherapy can help shrink triple-negative breast cancer faster, and lower the risk of the cancer coming back in other part of the body.
In addition to studying their effectiveness, the study is designed to find out how frequently patients have side effects from these treatments. We are also studying a number of biologic characteristics in the cancer cells and blood of patients like you to see whether those characteristics predict which patients are more likely to achieve a pCR and which patients may benefit from the addition of carboplatin and/or bevacizumab to the standard treatment regimen.

Eligibility and Treatment Plan:
Age 18 or older
Stage II-III invasive breast cancer with intent to perform surgical resection after neoadjuvant therapy
Invasive tumor must be hormone receptor-poor and HER2-negative
Patient must agree to undergo pretreatment research biopsies.

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