GOG-0249: A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal
Cuff Brachytherapy Followed by Paclitaxel/Carboplatin Chemotherapy in
Patients with High-Risk, Early Stage Endometrial Carcinoma
||Aliza Leiser, MD
| Time frame of study:
|Location of Study:
Mount Sinai Beth Israel
St.Luke's-Mount Sinai Roosevelt
Continuum Cancer Research Program
Patients who participate in this study have risk factors related to their
endometrial cancer that places them at greater risk for the cancer coming
back (recurrence). This trial compares a standard treatment (whole pelvic
radiation) to an investigational treatment (internal vaginal radiation
therapy followed by chemotherapy) in patients with high risk, early stage
endometrial cancer. In addition, this study will compare survival, side
effects, and differences in where cancer may recur in patients treated
with one of the two treatments, as well as look at how a patient’s
overall health and weight impact how well patients do and how these factors
affect a patient’s quality of life.
• All patients must have undergone hysterectomy. Bilateral removal
of fallopian tubes and ovaries is strongly encouraged.
• Patients with Stage II endometrial carcinoma with or without high-intermediate
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