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GOG-0249: A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/Carboplatin Chemotherapy in Patients with High-Risk, Early Stage Endometrial Carcinoma

Principal Investigator: Aliza Leiser, MD
Time frame of study: Ongoing
Location of Study:

Mount Sinai Beth Israel
St.Luke's-Mount Sinai West


Continuum Cancer Research Program
(212) 844-6286


Patients who participate in this study have risk factors related to their endometrial cancer that places them at greater risk for the cancer coming back (recurrence). This trial compares a standard treatment (whole pelvic radiation) to an investigational treatment (internal vaginal radiation therapy followed by chemotherapy) in patients with high risk, early stage endometrial cancer. In addition, this study will compare survival, side effects, and differences in where cancer may recur in patients treated with one of the two treatments, as well as look at how a patient’s overall health and weight impact how well patients do and how these factors affect a patient’s quality of life.

Eligibility and Treatment Plan:

• All patients must have undergone hysterectomy. Bilateral removal of fallopian tubes and ovaries is strongly encouraged.
• Patients with Stage II endometrial carcinoma with or without high-intermediate risk factors.

Please call for more information.



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