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Abiraterone Acetate Treatment for Prostate Cancer Patients with PSA of More Than Four Following Initial Androgen Deprivation Therapy, Phase II
Developing data suggests that the low levels of androgens that persist, despite androgen deprivation therapy, may play an important role in the development of castrate resistant prostate cancer (CRPC). Current therapies (orchiectomy and GNRH) cut androgen production by the testes but do not affect androgen production by the adrenals.
Abiraterone inhibits the conversion of progesterone into androstenedione,
which are 2 precursors of testosterone in the adrenal glands and testes.
Testosterone is further converted to the more potent androgen dihydrotestosterone
(DHT). Both testosterone and DHT stimulate prostatic growth.
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